It should. It is looking for a 4000PPM (high peak to low peak) signal. My stock speedometer worked with my 2001, 4T65e-HD sender, which is a Hall Effect type sender.
I have since swapped to an after market gauge, but it was working with my original.
The stock system is 4000PPM from VSS to Speedometer. The Speedometer converts the 4000PPM to a 2000PPM (VSS/2) signal for the ECM (and Cruise control).
-Dave
Adding:
If it does not, Dakota Digital makes a signal converter for the job.
[This message has been edited by IFLYR22 (edited 07-30-2013).]