I'm having a similar problem. I'm using a 7730 ECM with the $A1 code mask. I have TunerPro RT v5, and the A1 adx file. I have the serial port configured correctly (or at least, I think), and the ALDL cable (serial port version) is detected. But whenever I start data acquisition, I just get a constant stream of errors. I've tried it with the 10k resistor "on" and "off", with no change. And my data line is on pin M of the ALDL plug.
Blacktree, same situation except I don't get errors, it just sits there and doesn't do anything.
At the bottom where it says "Not emulating" and "DA: Not connected" what else should/shouldn't it say when your plugged into ALDL with/without engine on? Mine says "Hardware not found" all the time and "Not ready" most of the time...
I can send you a test set up that I use with a known working USB cable, a known working 7730 with MEM.CAL and a known working test cable that plugs into the 7730, connects to 12v and has an ALDL cable. Then you should be able to make some sense of what does work and then also come up with what is not working with your set up. There will be a core charge for the stuff, but then return whatever you don't use and I will refund the core charge for whatever you don't use.
ConvictedRedneck, did you ever figure this one out? I am having the same problem with Tunerpro RT on both a 1988 2.8 V6 using the $24 ads file from tunerpro.net (imported to an adx) and also on a 1988 2.5 using the 87-88_2.5.adx file from phonedawgz (thanks phonedawgz!). I connected the cable with jumpers using bare pins on the ALDL to be sure there was electrical connection, but it's stuck at attempting to communicate just like you said in your initial post. Tunerpro does recognize the USB cable. I am using a OBD Diagnostics 12 pin USB/ALDL cable with the 10kOhm jumpered in (so phonedawgz please don't flame me).
It also includes all the .ADX files already converted just in case that was the problem.
One thing that I have been having problems with is the version 2.08.28 FTDI FT232RL driver. After unziping my disk run AutoRun to get to my main menu. Under "Read First - Overview + Troubleshooting" look for "If you suspect the incompatible drivers were installed" and following the instructions check to see what version your drivers are, and if they are the .28 it also tells you how to change them, and the new (old) drivers are in the install disk.
If that doesn't fix things, in TunerPro RT, with the cable connected to the computer, but not connected to the ALDL port, do you get a "Cable Passed" indication at the COM PORT selection?