Okay, a low pass crossover built into an amp is probably 12 db per octave, Meaning, if you set it to 50 hz, 100 hz will be cut 12 db, 200 24 db, 400 36 db, 800 48 db and so on. 80 hz will be down 12 db at 160, 320 24 db, 640 36 db amd 1280 48 db. Basically what it boils down to is how much you want those upper frequencies cut. The 50 hz will cut out more midbass then the 80 hz. Best thing to do is try it both ways and see which one sounds better. If you cut it off to low you will have a gap in the midbass section. Cutt it off to high and the midbass section will be to loud. They have the 2 settings because they don't know what the end user is going to have in the car along with the sub and amp plus the physical acoustics of the car will make different settings more desireable. Most car naturally boost the bass a little bit, soit just depends what your car is boosting and what your other speakers are covering.
I have to agree with Doug85GT though. Those seem awful low points for a 6.5" sub. It's already going to have it's lower extension limited because of cone size. I don't think I've seen a 6.5 that get's down past 30 hz, where as 10"+ I've seen down to the 20hz range. Set at 50 hz, you may be really limiting what the speaker puts out. I usually set mine with 10's around the 100 hz area (but then my amp has a variable crossover so I can dial it in better).
Sorry for any spelling errors. I just got home from a BBQ and had several drinks.
[This message has been edited by Khw (edited 04-01-2012).]