Well... yes and no. VE is unchanged if you measure flow just in front of the throttle body. That's what I'd be inclined to do, as it makes the math easier. We can infer the stock engine's VE curve from the stock torque curve, which starts off at 275 ftlbs at 1,000 RPM or so and drops to 233 ftlbs at 4500 RPM ( I think peak horsepower is about 4500, more likely lower than higher, though), which translates to 66% at 1,000 RPM and about 56% at 4500 RPM. This will not change significantly unless there are mechanical changes made to the engine. You can then do what bushroot did and calculate mass flow at each RPM data point and use this information to figure out proper compressor sizing. I think there are a couple of 4.9 chassis dyno sheets somewhere on the forum. You could look at those curves, infer flywheel numbers, plug the data points and equations into a spreadsheet and have a really nice setup for computing compressor flow requirements.
In saying that VE will not change, I am intentionally ignoring the increase in back pressure due to the turbo. In other circumstances, this would hamper scavenging and reduce VE, but since this is a Caddy engine and has almost no valve overlap, I don't think the effect will be worth worrying about.
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'87 Fiero GT: Low, Sleek, Fast, and Loud
'90 Pontiac 6000 SE AWD: None of the AboveDo that again, only mean it this time