I am not intimately familiar with rotaries, but I'd compare the different geometries of the two motors. I've read on other forums that part of the reason converting a RX-7 to a 350 small block is so easy is the position of the power output of the engine.
Consider: The SBC crankshaft exits the back of the motor fairly low. The rotary, on the other hand, exits about the middle of the motor. That means that a car designed for a rotary engine will have a fairly high transmission tunnel, making it pretty easy to put any transmission you please behind the motor.
CONVERSLY, if you wanted to mate a rotary to a Fiero transmission you might have to mount the rotary so low (to preserve the proper relationship between the transmission output and the wheels) that it might drag the ground.
Hey, don't laugh! Like I said, I don't know that much about rotaries. But it's something to consider.