Nope, no issues with tuning, just slap the TPI intake and what not on ( requires what Rockcrawl said on 86 and earlier heads)
Actually its the 2 center holes on either side in the middle of the Intake manifold that need to be oblonged.
Add an O2, oil pressure switch/sender and knock sensor, wire it up and your good to go.
All the other needed sensors are mounted in the TPI intake and plenum.
If you choose to use the new style 86-up heads, those will bolt to the earlier blocks.
The new Vortec heads will not match up to the factory TPI intake if you think about going that route.
I used a 73 4 bolt main block, and the heads and TPI set up from a 91 350 F-bird.
Everything works perfect, and asthetically it looks proper other than the dipstick tube on the wrong side.
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1988GT T-Tops, 5spd, Loaded