The only slant 6 I know of was in Mopar cars in the 70's. I had a friend with a '70 Plymouth Duster with that engine. It was a good work horse of an engine, but hardly swap material in a newer car (let alone a Fiero!).
It is basically an inline 6 cylinder, but instead of straight up and down (like the iron duke) the cylinders are at an angle or slanted (hence the name).
Even if it were a great high powered engine (which it's not) it is way too long to fit inside the Fieros engine bay.....you figure all 6 cylinders are in a row, so it is probably close to twice as long as a 2.8.