Yep I used a cordless drill and bit. I looked on both sides to make sure nothing was in the way. You could use a hammer and punch first so you know where the hole will be by seeing the dimple from the punch.
Here is a pic of when it was done, the hole for the power wire is behind the amp. The power wire tucks up under the upper carpet piece and the hole us under there as well, so no holes were needed in the carpeting, except mounting the amp, which was just small self tappers through the upper carpeted board only. The rest of the wires to the radio run under that upper carpeting over to the center console and along side it under the carpeting. I used a nut as a spacer on each mounting screw for the amp, to keep a gap between it and the carperted board, this allowed space to run the audio wires behind it and helped cool it. My ground was actually an existing bolt in the center console area. (Under the "glove box"). The little shroud is just carpeted carboard which hides the amp when the seat is back.
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[This message has been edited by 2.5 (edited 02-06-2014).]