Just running a lower profile tire will jar the bushings ans shocks/struts more due to there being less "give" to the tire itself. how to measure or quantify that I dont really know. I do know if your wheel offset is too far out from stock it can become harder to turn the steering wheel, which could be a sign that things are being stressed more.
I know there are some wheel offset/lowering suspension experts on this forum, they may chime in on this stuff too.
[This message has been edited by 2.5 (edited 01-17-2014).]